Chromosome Studies in 2 Cases of Bovine Lymphosarcoma

Spontaneous neoplasms in sheep with report of cases of melanoma, mesothelioma and lymphosarcoma

Pathology of lymphosarcoma in sheep induced with bovine leukemia virus.

Sixty-nine sheep were infected with bovine leukemia virus from bovine lymphosarcoma materials. Twenty-four developed lymphosarcoma and died from 13 to 66 (average, 29) months later. Circulating lymphocytes were increased to leukemia levels (70,000 to 403,000/cu mm blood) in only eight sheep within 2 to 3 months of death. Various lymph nodes and visceral organs including heart, abomasum, uterus,...

Studies on cell lines derived from calf, thymic and skin forms of bovine lymphosarcoma.

The etiology of sporadic bovine leukosis (SBL) is not known. Long-term monolayer cultures were made from calf (CLS), thymic (TLS) and skin (SLS) forms, and serological tests, electron microscopic observations and reverse transcriptase assays were employed for the detection of an etiological agent. Bovine leukosis virus (BLV) antigen and reverse transcriptase activities remained negative in cult...

Nucleic acids of bovine lymphosarcoma and normal thymus.

Prior work has shown that mild alkaline hydrolysis of nuclei previously extracted with cold dilute acid and with lipid sol vents yielded not only the expected RNA nucleotides but also free adenine and guanine in amounts which varied in versely with the extent of preliminary lipid extraction. The nucleic acid of the nuclei was identified as the source of the free purines. The experiments describ...

Tumor-associated antigen in bovine and ovine lymphosarcoma.

Specific tumor-associated antigens were found on the membrane and in the cytoplasm of lymph node cells and peripheral blood lymphocytes (PBL) from cattle and sheep with lymphosarcoma by immunofluorescence tests. Materials from 15 cattle with the adult form of lymphosarcoma were examined. Cytoplasmic antigen was detected in fixed tumor cells from all 15 cases and in PBL from 9 cases tested. Memb...